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October 2019, FAM19A4/miR124-2 methylation as triage marker shows higher sensitivity than cytology for the detection of CIN3+ in women living with HIV
Researchers of the Amsterdam UMC in collaboration with clinicians and researcher of the University of Pretoria in South Africa have assessed the performance of molecular screening strategies for detection of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) in comparison with cytology screening in women living with HIV (Kremer et al, AIDS 2019). Cytology and human papillomavirus (HPV)-based strategies were evaluated on cervical scrapes from 318 women, including single test and FAM19A4/miR124-2 methylation triage strategies. The researchers concluded that molecular screening strategies using HPV, with or without HPV16/18 genotyping, and FAM19A4/miR124-2 methylation have higher sensitivity with an acceptable loss in specificity compared with current cytology screening and are efficient for the detection of CIN3+ in South African women living with HIV.